De-liver CLiPs and revitalize hepatocytes

Chlamydia, Hepatocytes and Liver

Ichthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

Toxic Effects of Cisplatin on Hepatocytes and Liver Enzymes of Rats

Introduction: Cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. However, its clinical usage is limited because of its side effects such as hepatotoxicity. This study aimed to identify toxic effects of cisplatin on hepatocytes of rats. Methods: A total of 45 adult Sprague Dawley rats weighing 200±30 g were randomly divided into ex...

Ichthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

Cryopreservation of Hepatocytes for Bioartificial Liver Devices

1 Introduction Supply of sufficient numbers of functional viable cells is one of the most controversial issues surrounding tissue and organ engineering. While use of autologous cells derived from the recipient patient is a feasible option for replacement of tissues such as cartilage, skin and bone, this is not a practical possibility for replacement of the function of organs such as liver. The ...